Protocol for behavioral tests using chemogenetically manipulated mice

Developing standardized behavioral tests for knockout and mutant mice.

The ability to produce transgenic, knockout, and mutant mice provides new animal models for the genetic analysis of behavior and its underlying neural mechanisms (Chen and Tonegawa 1997; Wehner et al. 1996). Knockout and transgenic mice have been developed as animal models for the study of human diseases such as Alzheimer's disease (Flood and Morley 1998; Nalbantoglu et al. 1997), Down's syndro...

Battery of behavioral tests in mice to study postoperative delirium

Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery of behavior tests, including natural and learned behavior, in mice to determine the effects of laparotomy under isoflurane anesthesia (Anesthesia/Surgery) on these behaviors...

Nociceptive Behavioral Tests

Identifying loci for behavioral traits using genome-tagged mice.

Identification of behavioral loci through complex trait mapping remains a widely employed approach but suffers from poor gene localization and low replicability. Genome-tagged mice (GTMs) are overlapping sets of congenic strains spanning the whole genome and offer the possibilities of superior mapping power and reproducibility. In this study, three GTM strains each consisting of an average appr...

[Selected problems of behavioral tests].

Changes in experimental animals' behavior as well as humans' behavior reflect even mild alterations in function of central nervous system. In order to detect those changes variety of tests' batteries were developed. With help of such unified tests it is possible to determine and differentiate individual behavioral parameters and establish their relation to specific CNS alterations. Behavioral t...